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They found that the risk for an adverse event was 2. 9 times higher in patients who had received at least four annual prescriptions for systemic. Increased risk of liver, kidney, and prostate cancer · high blood pressure, which increases the chance of. Acne · blurred vision · changes in behavior or mood · elevated blood pressure levels · elevated blood sugar levels · fluid retention · headache. There are four important ocular side effects of corticosteroids: steroid-induced glaucoma, cataract formation, delayed wound healing, and increased susceptibility. What side effects can this medication cause? what monitoring will i need? why is this medication being recommended? prednisone is part of a class of drugs. To reduce the risk of side effects, your doctor will usually prescribe a low dose for a short amount of time (three months or less). The longer you take the medication. 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